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Peripheral Intervention
February 8th, 2018

Embolization coils: Fibers or no fibers, that is the question

Nester® Embolization Coil

Researchers at Cook Research Incorporated (CRI) and Purdue University recently tested fibered vs. non-fibered Nester® Embolization Coils in porcine arteries to determine which type required fewer coils to effectively seal vessels.

There are multiple scientific research articles on the role of coating material or filament on embolization coils. However, the CRI research is specifically designed to show the role of synthetic fibers that are attached to Nester coils.

Nester coils are made of platinum with spaced synthetic fibers. The goal of this research is to show the role of the fibers in creating complete vessel occlusion in the short term, while controlling for other variables.

Results showed an average of 3.3 non-fibered coils were needed to achieve occlusion compared to 1.3 fibered coils. According to Nester Product Manager Heungseok Oh, those outcomes indicate that fibered coils create faster occlusion in the short term.

“When it comes to short-term embolization, Nester fibered coils performed nearly three times more effectively to occlude a vessel than non-fibered coils,” Heungseok said.

During the study, an interventional radiologist implanted fibered coils in two target arteries and non-fibered coils in two additional target arteries. A total of six pigs were used for 24 target vessel embolizations. The blinded randomized study ensured the operator did not know which type of coils he was deploying during the study. A maximum of four coils could be used in each artery.

Target arteries had a diameter of approximately 3.2 mm or less. Coil delivery ended once the vessel was occluded or after the maximum number of coils had been delivered.

Following deployment, an arteriogram was performed, and the interventional radiologist determined whether the coils migrated or if there was evidence of damage to the target artery. There was no evidence of coil migration and no observable damage to the coils or vessel walls.

“This animal study clearly shows the role of fibers in creating faster occlusion in the short term,” Heungseok said. “Further research will need to compare Cook’s fibered coils versus competitors’ coils. In addition, the long-term effects of fibered coil embolization need to be researched to show the role of fibers in the chronic setting.”