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January 5th, 2022

Cook Medical launches new Instinct Plus® Endoscopic Clipping Device with improved functionality and expanded indications

Bloomington, Ind. — Cook Medical’s Instinct Plus® Endoscopic Clipping Device is now commercially available to physicians in the United States. The new clipping device, based on the design of the original Instinct® Endoscopic Clip, features smoother operation and responsive handling1, strong clip retention2 and expanded indications beyond hemostasis and endoscopic marking, including compatibility through a side-viewing scope (also known as a duodenoscope), applications for defect closure, anchoring procedures and prophylactic clipping in the gastrointestinal (GI) tract.

Photo of Cook Medical's Instinct+ product

Cook Medical’s Instinct Plus Endoscopic Clipping Device

Bleeding in the upper GI tract is a leading cause of death in patients suffering from gastrointestinal disorders, and upper GI peptic ulcer bleeding is associated with up to 20,000 deaths per year in the United States alone.3 Clipping devices are used to close defects within the GI tract and to achieve hemostasis in a variety of endoscopic procedures, including bleeding associated with mucosal and submucosal defects, polyp resection and diverticulosis of the colon. When physicians are treating GI peptic ulcer bleeding, hemoclips are usually more effective at preventing rebleeding than injection therapy.4

“Clips are used in a wide variety of endoscopic procedures, but primarily for closure and hemostasis. Wherever the clips are placed, they’re an important tool for the physician and for their patients,” said Barry Slowey, president of Cook Winston-Salem and vice president of Cook Medical’s Endoscopy specialty. “Instinct Plus builds on the strengths of the original Instinct device. We’re very excited to offer physicians a tool that will provide them with more options for treating patients.”

Other features of the Instinct Plus clip include multiple anchoring tips on the clip to aid in dragging and holding tissue and an adjustable clipping span that opens up to 16 millimeters wide.

Instinct Plus is the newest addition to Cook Medical Endoscopy’s hemostasis portfolio, which includes Hemospray® Endoscopic Hemostat, the Saeed® Six Shooter® Multi-Band Ligator and the AcuJect® Variable Injection Needle.

Learn more about the Instinct Plus Endoscopic Clipping Device here.

About Cook Medical
Since 1963, Cook Medical has worked closely with physicians to develop technologies that eliminate the need for open surgery. Today we invent, manufacture and deliver a unique portfolio of medical devices to the healthcare systems of the world. Serving patients is a privilege, and we demand the highest standards of quality, ethics and service. We have remained family owned so that we have the freedom to focus on what we care about: patients, our employees and our communities.

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  1. Data on file. Force and throw at handle to approximate tissue and to open clip (with tissue) for Instinct generation 2. Test report 800008-35-R. September 13, 2019.
  2. Data on file. Deployed clip tissue dislodgement force post procedure (force of clip retention at tissue) and force of clip compression at tissue for Instinct generation 2. Test report 800008-10-R. August 8, 2019.
  3. El-Tawil AM. Trends on gastrointestinal bleeding and mortality: where are we standing? World J Gastroenterol. 2012;18(11):1154–1158.
  4. Baracat F, Moura E, Bernardo W, et al. Endoscopic hemostasis for peptic ulcer bleeding: systematic review and meta-analyses of randomized controlled trials. Surg Endosc. 2016;30(6):2155–2168.


Instinct Plus EPI

Essential prescribing information (EPI) for Cook Medical’s Instinct Plus Endoscopic Clipping Device